TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

作者：Carmine Settembre, Andrea Ballabio · 发表于：Autophagy · 年份：2011 · DOI：10.4161/auto.7.11.17166 · 被引用次数：253 · 研究领域：Autophagy in Disease and Therapy、Calcium signaling and nucleotide metabolism

Autophagy is a fundamental catabolic process that plays a central role in health and disease. An efficient autophagic process relies on the cooperation of two distinct types of organelles: the autophagosome and the lysosome. We have identified a gene network that regulates the biogenesis and function of both organelles. Our findings reveal an important role of transcription in the regulation of starvation-induced autophagy, and link lysosomal biogenesis to autophagy.