Treatment of Sialorrhea With Glycopyrrolate

作者：Richard J. Mier, Steven Bachrach, Ryan C. Lakin, Tara Barker, Judith Childs, Maria Moran · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：2000 · DOI：10.1001/archpedi.154.12.1214 · 被引用次数：197 · 研究领域：Botulinum Toxin and Related Neurological Disorders、Facial Rejuvenation and Surgery Techniques、Salivary Gland Disorders and Functions

OBJECTIVE: To determine the safety and efficacy of glycopyrrolate in the treatment of developmentally disabled children with sialorrhea. DESIGN: Placebo-controlled, double-blind, crossover dose-ranging study. SETTING: Outpatient facilities in 2 pediatric hospitals. PATIENTS: Thirty-nine children with both developmental disabilities and excessive and bothersome sialorrhea. MAIN OUTCOME MEASURES: Parent and investigator evaluation of change in sialorrhea and adverse effects. RESULTS: Glycopyrrolate in doses of 0.10 mg/kg per dose is effective at controlling sialorrhea. Even at low doses, 20% of children may exhibit adverse effects severe enough to require discontinuation. CONCLUSIONS: Glycopyrrolate is effective in the control of excessive sialorrhea in children with developmental disabilities. Approximately 20% of children given glycopyrrolate may experience substantial adverse effects, enough to require discontinuation of medication. Arch Pediatr Adolesc Med. 2000;154:1214-1218.