Limits of Neurogenesis in Primates

作者：PASKO T. RAKIC · 发表于：Science · 年份：1985 · DOI：10.1126/science.3975601 · 被引用次数：504 · 研究领域：Neurogenesis and neuroplasticity mechanisms、Memory and Neural Mechanisms、Neuroscience and Neuropharmacology Research

Systematic analysis of autoradiograms prepared from postpubertal rhesus monkeys given single and multiple injections of tritium-labeled thymidine and killed 3 days to 6 years later displayed a slow turnover of glial cells but failed to reveal any radiolabeled neurons. Therefore, unlike neurons of some nonprimate species, all neurons of the rhesus monkey brain are generated during prenatal and early postnatal life. A stable population of neurons in primates, including humans, may be important for the continuity of learning and memory over a lifetime.