Integrating phenotype ontologies across multiple species

作者：Chris Mungall, Georgios V. Gkoutos, Cynthia L. Smith, Melissa Anne Haendel, Suzanna E. Lewis, Michael Ashburner · 发表于：Genome biology · 年份：2010 · DOI：10.1186/gb-2010-11-1-r2 · 被引用次数：290 · 研究领域：Biomedical Text Mining and Ontologies、Semantic Web and Ontologies、Bioinformatics and Genomic Networks

Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.