Production of Polydipsia in Normal Rats by an Intermittent Food Schedule

作者：John L. Falk · 发表于：Science · 年份：1961 · DOI：10.1126/science.133.3447.195 · 被引用次数：719 · 研究领域：Electrolyte and hormonal disorders、Birth, Development, and Health、Ion Transport and Channel Regulation

Marked polydipsia was produced in all animals trained to press a bar for food pellets on a 1-minute variableinterval schedule. It is suggested that since this feeding arrangement produces a sustained, high fluid intake in the normal, unrestrained animal, it might serve as a useful tool in the study of renal function.