The First Applications of Carbene Ligands in Cross-Couplings of Alkyl Electrophiles: Sonogashira Reactions of Unactivated Alkyl Bromides and Iodides

作者：Matthias Eckhardt, Gregory C. Fu · 发表于：Journal of the American Chemical Society · 年份：2003 · DOI：10.1021/ja038177r · 被引用次数：433 · 研究领域：Catalytic Cross-Coupling Reactions、Chemical Reactions and Isotopes、Catalytic C–H Functionalization Methods

A Pd/N-heterocyclic carbene-based catalyst achieves the Sonogashira coupling of an array of functionalized, beta-hydrogen-containing alkyl bromides and iodides under mild conditions. By furnishing the first example of a nonphosphine-based palladium catalyst for cross-coupling unactivated alkyl electrophiles, this study provides an impetus for future efforts at catalyst development that extend beyond phosphine ligands.