Polymorphism of HLA‐B27 in Taiwanese Chinese

作者：Ke Yang, Ke Yang, I.‐H. Chen, Chuhsing Kate Hsiao, Jaw‐Ming Cherng, Kehao Yang, Kehao Yang, Christopher Chang, Ching‐Fa Yeh, Pei‐Ying Lin · 发表于：Tissue Antigens · 年份：2004 · DOI：10.1111/j.0001-2815.2004.00197.x · 被引用次数：24 · 研究领域：Spondyloarthritis Studies and Treatments、Dermatology and Skin Diseases、Rheumatoid Arthritis Research and Therapies

Heterogeneity of HLA-B27 is represented by a family of 24 closely related alleles/subtypes. Frequency and disease association of these alleles with spondyloarthropathies differ among ethnic groups. Accurate investigation of frequencies of alleles is often hindered by the size and demographic region of sample tested. With an ever-increasing number of B27 alleles being discovered, it is becoming imperative to establish disease association of each individual alleles and its biological importance. In a large number of normal healthy Taiwanese Chinese individuals (75,777) tested nationally, over a period of five years, in a single immunogenetics centre, we found additional B27 subtypes not revealed in a previous Taiwanese Chinese population study. The subtypes found in Taiwanese Chinese and the frequencies of each of the subtypes are reported.