NMR chemical shift imaging in three dimensions.

作者：Truman R. Brown, B. M. Kincaid, Kǎmil Uǧurbil · 发表于：Proceedings of the National Academy of Sciences · 年份：1982 · DOI：10.1073/pnas.79.11.3523 · 被引用次数：1040 · 研究领域：NMR spectroscopy and applications、Advanced MRI Techniques and Applications、Advanced NMR Techniques and Applications

A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an "image" of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.