Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis.

作者：Thaddeus Zajdowicz, Priscila Lima Sanches, S. WILLIAM BERG, Sharon Kerbs, R L Newquist, William O. Harrison · 发表于：Sexually Transmitted Infections · 年份：1983 · DOI：10.1136/sti.59.3.176 · 被引用次数：36 · 研究领域：Neuropeptides and Animal Physiology、Pneumocystis jirovecii pneumonia detection and treatment、Pharmacological Receptor Mechanisms and Effects

Since cefoxitin has been shown to be an effective alternative to spectinomycin for the treatment of infections due to penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) its efficacy was compared with that of a new cephalosporin, ceftriaxone (R013-9904). One hundred and twenty eight men with culture-confirmed gonococcal urethritis were treated with either 250 mg of ceftriaxone intramuscularly or 2 g of cefoxitin intramuscularly with oral probenecid 1 g. The incidence of penicillin-resistant strains in each group was about 60%. Ceftriaxone was completely effective in treating both penicillin-sensitive and penicillin-resistant gonococcal urethritis. No side effects were noted. Ceftriaxone thus seems to be an effective and safe alternative to either spectinomycin or cefoxitin in the treatment of penicillin-resistant gonococcal urethritis.