Ectopic lipid storage and insulin resistance: a harmful relationship

作者：Jan Borén, Marja‐Riitta Taskinen, S.‐O. Olofsson, Malin C. Levin · 发表于：Journal of Internal Medicine · 年份：2013 · DOI：10.1111/joim.12071 · 被引用次数：235 · 研究领域：Lipid metabolism and biosynthesis、Adipose Tissue and Metabolism、Pancreatic function and diabetes

Obesity increases the risk of metabolic diseases, including insulin resistance and type 2 diabetes, as well as cardiovascular disease. In addition to lipid accumulation in adipose tissue, obesity is associated with increased lipid storage in ectopic tissues, such as skeletal muscle and liver. Furthermore, lipid accumulation in the heart may result in cardiac dysfunction and heart failure. It has recently been demonstrated that intracellular lipid accumulation in ectopic tissues leads to pathological responses and impaired insulin signalling. Here, we will review the current understanding of how lipid storage and lipid droplet physiology affect the risk of developing metabolic diseases.