A DIFFERENCE IN THE ARCHITECTURE OF THE SURFACE MEMBRANE OF NORMAL AND VIRALLY TRANSFORMED CELLS

作者：Max M. Burger · 发表于：Proceedings of the National Academy of Sciences · 年份：1969 · DOI：10.1073/pnas.62.3.994 · 被引用次数：549 · 研究领域：Animal Virus Infections Studies、RNA and protein synthesis mechanisms、Bacteriophages and microbial interactions

Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same agglutinin receptor sites in a fashion indistinguishable from the transformed cells, it is proposed that both viral and chemical transformation produce changes in the architecture of the membrane, identical to those of the proteases.