Diagnostic challenges in minimal deviation adenocarcinoma of the uterine cervix: A report of two cases and review of the literature

作者：Feifei Guo, Yali Hu, Xiaofeng Xu, Rong Li, Tong Ru, Jingmei Wang, Huaijun Zhou · 发表于：Molecular and Clinical Oncology · 年份：2013 · DOI：10.3892/mco.2013.144 · 被引用次数：11 · 研究领域：Endometrial and Cervical Cancer Treatments、Uterine Myomas and Treatments、Endometriosis Research and Treatment

Minimal deviation adenocarcinoma (MDA) of the uterine cervix, otherwise known as adenoma malignum, is a rare variant of cervical adenocarcinoma, which represents a diagnostic challenge in the field of gynecologic oncology, due to its benign-resembling histological characteristics. To achieve a better understanding of this disease, we present two cases of MDA: one case presented with profuse watery discharge and cervical enlargement, accompanied by retention cysts and hardening; the other presented with a history of myoma cervicis uteri. Both patients underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy and our follow-up indicated that the patients were still free of any disease. Subsequently, a literature review was performed and the results demonstrated that early diagnosis, clinical stage and surgical protocols are the main factors affecting the prognosis of MDA. Close follow-up of the cases may provide more information regarding this disease and the efficacy of the available therapeutic methods.