Preparation of Unsymmetrical Biaryls by Pd(II)-Catalyzed Cross-Coupling of Aryl Iodides

作者：Liqiang Wang, Wenjun Lü · 发表于：Organic Letters · 年份：2009 · DOI：10.1021/ol802865c · 被引用次数：37 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Chemical synthesis and alkaloids

The Ullmann homo- and cross-couplings of aryl iodides are carried out to afford symmetrical and unsymmetrical biaryls in moderate to good yields in a catalytic system of Pd(OAc)(2)/K(2)CO(3)/MeCOEt. The high selectivity of unsymmetrical biaryl products in cross-couplings mainly depends on the reactivity difference between two iodoarene substrates and their employed ratios.