Requirement of Mip-1α for an Inflammatory Response to Viral Infection

作者：Donald N. Cook, Melinda A. Beck, Thomas M. Coffman, Suzanne L. Kirby, John F. Sheridan, lan B. Pragnell, Oliver Smithies · 发表于：Science · 年份：1995 · DOI：10.1126/science.7667639 · 被引用次数：635 · 研究领域：Chemokine receptors and signaling、Kawasaki Disease and Coronary Complications、Viral Infections and Immunology Research

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.