Diabetes, a New Mutation in the Mouse

作者：Katharine Pattee Hummel, Margaret M. Dickie, Douglas L. Coleman · 发表于：Science · 年份：1966 · DOI：10.1126/science.153.3740.1127 · 被引用次数：1001 · 研究领域：Pancreatic function and diabetes、Adipose Tissue and Metabolism、Metabolism, Diabetes, and Cancer

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.