Fetal hepatic haematopoiesis is modulated by arterial blood flow to the liver

作者：Shaun M. Kunisaki, Humberto Azpurua, Julie R. Fuchs, Sara C. Graves, David Zurakowski, Dario O. Fauza · 发表于：British Journal of Haematology · 年份：2006 · DOI：10.1111/j.1365-2141.2006.06183.x · 被引用次数：9 · 研究领域：Zebrafish Biomedical Research Applications、Pregnancy and preeclampsia studies、Birth, Development, and Health

We describe an as yet unrecognised relationship between fetal hepatic haematopoiesis and arterial blood flow to the liver. To increase hepatic arterial flow, the common bile duct (CBD) was ligated in fetal lambs. Reduction of hepatic arterial flow was accomplished in age-matched animals by hepatic artery (HA) ligation. Multiple analyses performed before term showed a significant increase in haematopoietic cell density in CBD animals when compared with sham controls and HA animals. In contrast, HA animals demonstrated a decrease in liver haematopoietic activity. Fetal hepatic haematopoiesis is dependent upon arterial blood flow to the liver.