Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters

作者：De-Yang Zhang, Fu‐Lin Zhu, Yahui Wang, Xin‐Hu Hu, Xin-Hu Hu, Song Chen, Chuan‐Jin Hou, Xiang‐Ping Hu, Xiang‐Ping Hu · 发表于：Chemical Communications · 年份：2014 · DOI：10.1039/c4cc06863g · 被引用次数：54 · 研究领域：Catalytic Alkyne Reactions、Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods

The first highly diastereo- and enantioselective propargylic alkylation of acyclic ketone enamines to form vicinal tertiary stereocenters has been reported by employing copper catalysis in combination with a bulky and structurally rigid tridentate ketimine P,N,N-ligand.