Preparation of Native Chromatin and Damage Caused by Shearing

作者：Markus Noll, Jean Olwen Thomas, Roger D. Kornberg · 发表于：Science · 年份：1975 · DOI：10.1126/science.187.4182.1203 · 被引用次数：415 · 研究领域：Genomics and Chromatin Dynamics

Chromatin prepared by a method involving limited nuclease digestion contains the same repeating structure as chromatin in the nucleus, whereas chromatin prepared by conventional methods involving shear does not.