The Taxonomy of Developmental Control in Caenorhabditis elegans

作者：Gary Ruvkun, Oliver Hobert · 发表于：Science · 年份：1998 · DOI：10.1126/science.282.5396.2033 · 被引用次数：308 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Pluripotent Stem Cells Research、Reproductive Biology and Fertility

The Caenorhabditis elegans genome sequence was surveyed for transcription factor and signaling gene families that have been shown to regulate development in a variety of species. About 10 to 25 percent of the genes in most of the gene families already have been genetically analyzed in C. elegans, about half of the genes detect probable orthologs in other species, and about 10 to 25 percent of the genes are, at present, unique to C. elegans. Caenorhabditis elegans is also missing genes that are found in vertebrates and other invertebrates. Thus the genome sequence reveals universals in developmental control that are the legacy of metazoan complexity before the Cambrian explosion, as well as genes that have been more recently invented or lost in particular phylogenetic lineages.