Leisure‐Time Physical Activity and Reduced Plasma Levels of Obesity‐Related Inflammatory Markers

作者：Tobias Pischon, Susan E. Hankinson, Gökhan S. Hotamışlıgil, Nader Rifai, Eric B. Rimm · 发表于：Obesity Research · 年份：2003 · DOI：10.1038/oby.2003.145 · 被引用次数：248 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Exercise and Physiological Responses、Inflammatory Biomarkers in Disease Prognosis

OBJECTIVE: This study investigated the relationship between physical activity and the obesity-related inflammatory markers C-reactive protein, interleukin-6, and soluble tumor necrosis factor receptors (sTNF-Rs) 1 and 2. Furthermore, we examined the relationship between physical activity and insulin sensitivity (insulin, C-peptide, and hemoglobin A(1c) levels) and whether inflammatory markers mediate this association. RESEARCH METHODS AND PROCEDURES: Biomarkers were measured in 405 healthy men and 454 healthy women from two large ongoing prospective studies. Information about physical activity and other variables was assessed by questionnaires. RESULTS: After adjustment for other predictors of inflammation, physical activity was inversely associated with plasma levels of sTNF-R1, sTNF-R2, interleukin-6, and C-reactive protein (p = 0.07, p = 0.004, p = 0.04, and p = 0.009). After further adjustment for BMI and leptin, as a surrogate for fat mass, most of these associations were no longer significant. Physical activity was also inversely related to insulin and C-peptide levels (p = 0.008 and p < 0.001); however, in contrast to BMI and leptin, levels of inflammatory markers explained only very little of this inverse relationship. DISCUSSION: These results suggest that frequent physical activity is associated with lower systemic inflammation and improved insulin sensitivity. These associations can partially be explained by a lower degree of obesity in physically active subjects. ...