Does brain 3,4-dihydroxyphenylacetic acid reflect dopamine release?

作者：Patrı́cio Soares-da-Silva · 发表于：Journal of Pharmacy and Pharmacology · 年份：1987 · DOI：10.1111/j.2042-7158.1987.tb06958.x · 被引用次数：25 · 研究领域：Neurotransmitter Receptor Influence on Behavior、Receptor Mechanisms and Signaling、Neuroscience and Neuropharmacology Research

After sulpiride (75 mg kg-1) administration, a significant increase in dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) occurred in the rat striatum. No attenuation in the sulpiride-induced dopamine and DOPAC increase was seen in the striatum from rats previously treated with benztropine (25 mg kg-1). On the other hand, in the benztropine + sulpiride-treated group, HVA levels were significantly lower compared with those of rats to which only sulpiride had been given. The results presented suggest that under appropriate conditions, as when sulpiride is used, dopamine can be deaminated before its release has occurred.