Erythropoietic Effect of Cobalt in Patients with or without Anemia

作者：Lionel Berk, Joseph H. Burchenal, William B. Castle · 发表于：New England Journal of Medicine · 年份：1949 · DOI：10.1056/nejm194905122401903 · 被引用次数：117 · 研究领域：Erythrocyte Function and Pathophysiology、Hemoglobinopathies and Related Disorders、Hematological disorders and diagnostics

COBALT in the form of one of its salts, usually cobaltous chloride or cobaltous nitrate, has been shown to produce polycythemia in amphibia, birds and mammals.1 2 3 In mammals the increased concentration of red blood cells in the circulation is due, as in other types of polycythemia, largely to an increase in the circulating red-cell mass.4 , 5 That the polycythemia is produced by increased red-cell production is indicated by an initial or by a maintained reticulocytosis,6 , 7 and an increase in erythroid cells in the bone marrow8 , 9 and in extramedullary locations.9 In some species the slight bilirubinemia7 presumably results from a partially compensatory . . .