Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction

作者：Jinkwon Kim, Young Dae Kim, Tae-Jin Song, Ji Eun Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Ji Hoe Heo · 发表于：Thrombosis and Haemostasis · 年份：2012 · DOI：10.1160/th12-03-0165 · 被引用次数：153 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Adipokines, Inflammation, and Metabolic Diseases、Blood properties and coagulation

Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outcome and mortality. A total of 847 consecutive patients with first-ever acute cerebral infarction who presented to the emergency department within seven days of symptom onset were enrolled in this study. We investigated the association of RDW with poor functional outcome (modified Rankin Scale >2) and all-cause mortality at three months, as well as survival time for one year after stroke onset. Multivariate logistic regression revealed that higher RDW was independently associated with poor functional outcome (adjusted odds ratio [OR], 1.222 per 1% increment in RDW, 95% confidence interval [CI] 1.059-1.409, p=0.006) and all-cause death (adjusted OR, 1.395 per 1% increment in RDW, 95% CI 1.168-1.665, p<0.001) at three months after stroke onset. RDW was an independent predictor of survival in multivariate Cox-proportional regression model (adjusted hazard ratio, 1.328 per 1% increment in RDW, 95%CI 1.178-1.498, p<0.001). The addition of RDW to a survival model significantly increased predictability for survival across the entire follow-up period (weighted average of the area-under the curves, 0.858 vs. 0.841, p<0.05). In conclusion, higher RDW measured in cases of acu...