Persistence of the Entire Epstein-Barr Virus Genome Integrated into Human Lymphocyte DNA

作者：Takumi Matsuo, M Heller, Lisa M. Petti, Eric M. Oshiro, Elliot Kieff · 发表于：Science · 年份：1984 · DOI：10.1126/science.6095452 · 被引用次数：154 · 研究领域：Viral-associated cancers and disorders、Lymphoma Diagnosis and Treatment、Parvovirus B19 Infection Studies

The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.