T-Independent Immune Response: New Aspects of B Cell Biology

作者：Sidonia Fagarasan, Tasuku Honjo · 发表于：Science · 年份：2000 · DOI：10.1126/science.290.5489.89 · 被引用次数：414 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.