Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK

作者：Michael W. Vitalini, Renato M. de Paula, Charles S. Goldsmith, Carol Jones, Katherine A. Borkovich, Deborah Bell‐Pedersen · 发表于：Proceedings of the National Academy of Sciences · 年份：2007 · DOI：10.1073/pnas.0704900104 · 被引用次数：75 · 研究领域：Circadian rhythm and melatonin、Genetics, Aging, and Longevity in Model Organisms、Light effects on plants

Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for osmotic stress responses, is a circadian output pathway that regulates daily rhythms in the expression of downstream genes. Rhythmic activation of the highly conserved stress-activated p38-type MAPK [Osmotically Sensitive-2 (OS-2)] by the N. crassa circadian clock allows anticipation and preparation for hyperosmotic stress and desiccation that begin at sunrise. These results suggest a conserved role for MAPK pathways in circadian rhythmicity.