Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase

作者：Naseema M. Hoosein, Ruth S. Gurd · 发表于：FEBS Letters · 年份：1984 · DOI：10.1016/0014-5793(84)81245-4 · 被引用次数：115 · 研究领域：Diabetes Treatment and Management、Pancreatic function and diabetes、Neuropeptides and Animal Physiology

Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [125I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP-1 and GLP-2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30-50 pM concentrations of each peptide elicited half-maximal adenylate cyclase stimulation. Our data suggest that GLP-1 and GLP-2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution.