Epidemiology and Estimated Population Burden of Selected Autoimmune Diseases in the United States

作者：Denise L. Jacobson, Stephen J. Gange, Noel R. Rose, Neil M.H. Graham · 发表于：Clinical Immunology and Immunopathology · 年份：1997 · DOI：10.1006/clin.1997.4412 · 被引用次数：1684 · 研究领域：Systemic Sclerosis and Related Diseases、Systemic Lupus Erythematosus Research、Celiac Disease Research and Management

Autoimmune diseases cause significant and chronic morbidity and disability. The actual number of persons in the United States that are affected by autoimmune diseases and the resultant magnitude of their impact on the public's health are limited to a few specific diseases. In order to understand the clinical, public health and economic importance of these diseases it is necessary to have estimates of incidence and prevalence rates in the population. In this analysis, we estimate the number of persons affected by 24 autoimmune diseases in the United States by applying mean weighted prevalence and incidence rates obtained from published articles to U. S. Census data. The study was restricted to 24 autoimmune predefined diseases for which there was direct or indirect evidence for autoimmune pathogenesis. Subsequently, we used computerized search software and ancestry searching (bibliographies) to conduct a comprehensive search of articles published from 1965 to the present. Eligible studies included those which adhered to standard disease definitions and which included population-based estimates of incidence or prevalence rates. Mean weighted incidence and prevalence rates were calculated from eligible published studies with greater weight proportionately given to larger studies. The mean rates were then applied to the U.S. Census population figures to estimate the number of persons currently afflicted with each disease and the number of new cases occurring each year in the Unit...