Type I collagen metabolites as tumor markers in patients with lung carcinoma

作者：Tetsu Kobayashi, Esteban Cesar Gabazza, Osamu Taguchi, Juha Risteli, Leila Risteli, Hiroyasu Kobayashi, Hiroki Yasui, Hisamichi Yuda, Takashi Sakai, 正徳 金田, Yukihiko Adachi · 发表于：Cancer · 年份：1999 · DOI：10.1002/(sici)1097-0142(19990501)85:9<1951::aid-cncr11>3.0.co;2-h · 被引用次数：33 · 研究领域：Proteoglycans and glycosaminoglycans research、Advanced Proteomics Techniques and Applications、Protease and Inhibitor Mechanisms

BACKGROUND: Components of the extracellular matrix play a fundamental role in the process of tumor invasion. The objective of this study was to evaluate the value of Type I collagen metabolites as tumor markers in patients with lung carcinoma. METHODS: In this study, the serum concentrations of the cross-linked carboxyterminal telopeptide of Type I collagen (ICTP) and the aminoterminal propeptide of Type I collagen (PINP) were measured in 59 consecutive patients with lung carcinoma. The blood concentrations of neuron-specific enolase (NSE), carcinoembryogenic antigen (CEA), sialyl Le-1 antigen (SLX), squamous cell carcinoma antigen (SCC), and D-dimer were also evaluated. Data obtained on 18 age-matched healthy subjects and 12 age-matched patients with benign lung disease were available for comparison. RESULTS: The serum concentrations of PINP were significantly higher in patients with lung carcinoma than in age-matched controls. Prechemotherapy values of PINP and ICTP were significantly increased in patients who did not respond to chemotherapy compared with those who did respond. PINP and ICTP were significantly correlated with clinical stage, extent of bone metastasis, survival time, and D-dimer. PINP was also significantly correlated with tumor size. ICTP was significantly correlated with CEA, SLX, SCC, and NSE. PINP also tended to correlate with these tumor-associated glycoproteins. PINP had a better receiver operating characteristic curve than ICTP. The specificity of PIN...