Coping and Immunosuppression: Inescapable But Not Escapable Shock Suppresses Lymphocyte Proliferation

作者：Mark L. Laudenslager, Susan M. Ryan, Robert C. Drugan, Richard L. Hyson, Steven F. Maier · 发表于：Science · 年份：1983 · DOI：10.1126/science.6603018 · 被引用次数：446 · 研究领域：Stress Responses and Cortisol、Tryptophan and brain disorders、Diabetes and associated disorders

Rats were given series of escapable shocks, identical inescapable shocks, or no shock. The subjects were reexposed to a small amount of shock 24 hours later, after which an in vitro measure of the cellular immune response was examined. Lymphocyte proliferation in response to the mitogens phytohemagglutinin and concanavalin A was suppressed in the inescapable shock group but not in the escapable shock group. This suggests that the controllability of stressors is critical in modulating immune functioning.