Disseminated sporotrichosis in patients with AIDS

作者：Howard M. Heller, Jack Fuhrer · 发表于：AIDS · 年份：1991 · DOI：10.1097/00002030-199110000-00014 · 被引用次数：90 · 研究领域：Fungal Infections and Studies、Antifungal resistance and susceptibility、Plant Pathogens and Fungal Diseases

Sporotrichosis is the disease caused by the dimorphic fungus Sporothrix schenkii. Disseminated sporotrichosis is an uncommon infection which usually occurs in alcoholics or patients receiving immunosuppressive medication. We report a case of a patient with AIDS who had disseminated sporotrichosis which was progressive and fatal despite antifungal therapy. Four previously reported cases of disseminated sporotrichosis in patients with AIDS are reviewed. Disseminated sporotrichosis occurs in patients with HIV-1 infection and severe CD4 lymphocyte depletion. It usually presents with diffuse cutaneous lesions and is associated with polyarticular arthritis. Response to treatment is variable and chronic suppressive therapy is probably needed to prevent relapse.