An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

作者：Malay Patra, Andreas Bauman, Cristina Mari, Christiane Fischer, Olivier Blacque, Daniel Häußinger, Gilles Gasser, Thomas L. Mindt · 发表于：Chemical Communications · 年份：2014 · DOI：10.1039/c4cc05558f · 被引用次数：161 · 研究领域：Radiopharmaceutical Chemistry and Applications、Medical Imaging Techniques and Applications、Medical Imaging and Pathology Studies

(89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.