Potent selective inhibitors of protein kinase C

作者：Peter D. Davis, Christopher H. Hill, Elizabeth Keech, Geoffrey Lawton, John Nixon, Anthony D. Sedgwick, Julie Wadsworth, Donald Westmacott, Sandra E. Wilkinson · 发表于：FEBS Letters · 年份：1989 · DOI：10.1016/0014-5793(89)81494-2 · 被引用次数：480 · 研究领域：Protein Kinase Regulation and GTPase Signaling、Microbial Metabolism and Applications、Phytochemistry and Bioactive Compounds

A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).