Delay to institution of therapy and induction of remission using single‐drug or combination–disease‐modifying antirheumatic drug therapy in early rheumatoid arthritis

作者：Timo T Möttönen, Pekka Hannonen, Markku Korpela, Martti Nissilä, Hannu Kautiainen, Jorma Ilonen, Leena Laasonen, Oili Kaipiainen‐Seppänen, Per Franzen, T. Helve, J. M. Koski, Marianne Gripenberg-Gahmberg, R Myllykangas-Luosujärvi, Marjatta Leirisalo‐Repo · 发表于：Arthritis & Rheumatism · 年份：2002 · DOI：10.1002/art.10135 · 被引用次数：420 · 研究领域：Rheumatoid Arthritis Research and Therapies、Chronic Lymphocytic Leukemia Research、Systemic Lupus Erythematosus Research

Abstract Objective To study the impacts of 1) the delay from the onset of symptoms to the institution of disease‐modifying antirheumatic drug (DMARD) therapy, 2) two treatment strategies (treatment with a combination of DMARDs or with a single drug), and 3) the presence of HLA–DRB1 alleles (shared epitope) on the prediction of disease remission after 2 years in patients with early rheumatoid arthritis (RA). Methods In the FIN‐RACo (FINnish Rheumatoid Arthritis Combination therapy) trial, 195 patients with recent‐onset RA (median duration 6 months) were randomly assigned to receive either 1) a combination of DMARDs (sulfasalazine, methotrexate, hydroxychloroquine, and prednisolone) or 2) a single DMARD with or without prednisolone. The presence of a shared epitope was tested for in 165 of the 178 patients completing the study. The additional variables of age, sex, presence of rheumatoid factor, number of fulfilled American College of Rheumatology criteria for the classification of RA, and length of delay from onset of symptoms to institution of therapy were entered into a logistic regression model to determine the significant predictors for remission at 2 years. Results The delay to therapy (cut point of 4 months) was the only significant predictor for remission in patients treated using the single‐DMARD strategy, while no variable was a significant predictor for remission in those treated using the combination‐DMARD strategy. The frequency of achieving remission in the combin...