The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.

作者：Clemens A. Dahinden, Y Kurimoto, A. L. DE WECK, Ivan J. D. Lindley, Béatrice Dewald, Marco Baggiolini · 发表于：The Journal of Experimental Medicine · 年份：1989 · DOI：10.1084/jem.170.5.1787 · 被引用次数：182 · 研究领域：Asthma and respiratory diseases、Cancer, Stress, Anesthesia, and Immune Response、Inhalation and Respiratory Drug Delivery

IgE-independent mediator release from basophils is considered an important event in inflammation, particularly in nonallergic immediate hypersensitivity and in allergic late-phase reactions. This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1. Thus, the sequential action of two pure cytokines can promote basophils mediator release. In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions.