ICE-related proteases in apoptosis

作者：Atsushi Takahashi, William C. Earnshaw · 发表于：Current Opinion in Genetics & Development · 年份：1996 · DOI：10.1016/s0959-437x(96)90010-6 · 被引用次数：162 · 研究领域：Cell death mechanisms and regulation、Phagocytosis and Immune Regulation、Protein Kinase Regulation and GTPase Signaling

Apoptotic execution involves numerous enzymatic pathways, all of which appear to be triggered by the activation of one or more ICE-related proteases (IRPs). Considerable effort is currently being expended in the identification and functional characterization of the rapidly expanding superfamily of IRPs. Important questions that remain unsolved include the identity of the vertebrate IRP that triggers the apoptotic cascade and the identities of the crucial substrates whose cleavage results in the dramatic morphological changes during apoptosis.