EPSTEIN-BARR VIRUS-INDUCED POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS

作者：Carlos V. Payá, John J. Fung, Michael A. Nalesnik, Elliott D. Kieff, Michael Green, Gregory Gores, Thomas Matthew Habermann, Russell H. Wiesner, Lode J. Swinnen, E. Steve Woodle, Jonathan S. Bromberg · 发表于：Transplantation · 年份：1999 · DOI：10.1097/00007890-199911270-00015 · 被引用次数：538 · 研究领域：Viral-associated cancers and disorders、Polyomavirus and related diseases、Cytomegalovirus and herpesvirus research

Epstein-Barr virus-induced posttransplant lymphoproliferative disease (EBV-PTLD) continues to be a major complication after solid organ transplantation in high-risk patients. Despite the identification of risk factors that predispose patients to develop EBV-PTLD, limitations in our knowledge of its pathogenesis, variable criteria for establishing the diagnosis, and lack of randomized studies addressing the prevention and treatment of EBV-PTLD hamper the optimal management of this transplant complication. This review summarizes the current knowledge of EBV-PTLD and, as a result of two separate international meetings on this topic, and provides recommendations for future areas of study.