Mitochondrial permeability transition and oxidative stress

作者：Alicia Juliana Kowaltowski, Roger Frigerio Castilho, Aníbal Eugênio Vercesi · 发表于：FEBS Letters · 年份：2001 · DOI：10.1016/s0014-5793(01)02316-x · 被引用次数：835 · 研究领域：Mitochondrial Function and Pathology、Metabolism and Genetic Disorders、Infectious Encephalopathies and Encephalitis

Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.