New implications for the QUAKING RNA binding protein in human disease

作者：Carol Anne Chénard, Stéphane Richard · 发表于：Journal of Neuroscience Research · 年份：2007 · DOI：10.1002/jnr.21485 · 被引用次数：130 · 研究领域：RNA Research and Splicing、RNA regulation and disease、RNA modifications and cancer

The use of spontaneously occurring mouse models has proved to be a valuable tool throughout the years to delineate the signals required for nervous system development. This is especially true in the field of myelin biology, with a large number of different models available. The quaking viable mouse models dysmyelination in the nervous system and links the QUAKING RNA binding proteins to myelination and cell fate decisions. In this Mini-Review, we highlight the biological functions attributed to this KH-type RNA binding protein and the recent achievements linking it to human disorders.