The Cellular Functions of Small GTP-Binding Proteins

作者：Alan K. Hall · 发表于：Science · 年份：1990 · DOI：10.1126/science.2116664 · 被引用次数：876 · 研究领域：Cellular transport and secretion、Protein Kinase Regulation and GTPase Signaling、Biochemical and Molecular Research

A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.