Iron overload impairs proliferation of erythroid progenitors cells (BFU-E) from patients with myelodysplastic syndromes

作者：Julia Hartmann, Friederike Braulke, Ursula Sinzig, Gerald Wulf, Jens Holger Maas, Frank Konietschke, Detlef Haase · 发表于：Leukemia Research · 年份：2012 · DOI：10.1016/j.leukres.2012.11.005 · 被引用次数：75 · 研究领域：Acute Myeloid Leukemia Research、Hemoglobinopathies and Related Disorders、Myeloproliferative Neoplasms: Diagnosis and Treatment

In patients with myelodysplastic syndromes (MDS) iron overload caused by long-term red blood cell transfusions is an important factor for comorbidity especially in low-risk MDS. In this report we present the results of a comparative study based on colony formation assays of hematopoietic cells in MDS patients with and without iron overload. We demonstrate that iron overload suppresses the proliferation of erythroid progenitors cells (BFU-E), while the myeloid compartment (CFU-GM) was not found to be affected. Even patients with slightly elevated ferritin values show an impaired proliferation capacity in comparison to patients with normal ferritin levels. Furthermore, we show that this negative impact is reversible by sufficient iron chelation therapy.