The mode of action of l,2-benzisothiazolin-3-one on Staphylococcus aureus

作者：Stephanie Jane Fuller, S.P. Denyer, W. B. Hugo, Darrel J. Pemberton, P.M. Woodcock, A Buckley · 发表于：Letters in Applied Microbiology · 年份：1985 · DOI：10.1111/j.1472-765x.1985.tb01478.x · 被引用次数：47 · 研究领域：Phenothiazines and Benzothiazines Synthesis and Activities、Quinazolinone synthesis and applications、Antimicrobial Resistance in Staphylococcus

1,2‐benzisothiazolin‐3‐one (BIT), at growth inhibitory concentrations, has little effect on membrane integrity but significantly inhibits the active transport and oxidation of glucose by washed Staphylococcus aureus cells. The dependancy of these metabolic processes on thiol‐containing enzymes and the observed interaction of BIT with glutathione and isolated enzyme preparations suggests that cellular thiol groups are a major target for BIT.