Characterization of suppressor cells involved in regulation of experimental allergic encephalomyelitis

作者：Andrew M. Welch, Robert H. Swanborg · 发表于：European Journal of Immunology · 年份：1976 · DOI：10.1002/eji.1830061214 · 被引用次数：45 · 研究领域：Immune Response and Inflammation、Immunotherapy and Immune Responses、T-cell and B-cell Immunology

Abstract This report describes studies carried out in an effort to identify the suppressor cells involved in the regulation of experimental allergic encephalomyelitis (EAE) in the Lewis rat. Viable lymph node cells (LNC) from donors rendered tolerant to clinical EAE by pretreatment with myelin basic protein antigen in nonencephalitogenic form are capable of transferring unresponsiveness to syngeneic recipients. Adoptive transfer of unresponsiveness was abrogated if LNC were treated in vitro with anti‐thymocyte serum and complement. In further experiments, it was shown that suppressor cells are among the LNC subpopulations that do not adhere to glass wool. These findings suggest that the immunoregulatory cells in EAE are suppressor T lymphocytes.