Antitumor Agents, 82. Cytotoxic Sapogenols from Aesculus hippocastanum

作者：Takao Konoshima, Kuo-Hsiung Lee · 发表于：Journal of Natural Products · 年份：1986 · DOI：10.1021/np50046a015 · 被引用次数：56 · 研究领域：Phytochemical Studies and Bioactivities、Natural product bioactivities and synthesis、Cancer Treatment and Pharmacology

Two cytotoxic sapogenols, the new hippocaesculin (1) and the known barringtogenol-C 21-angelate (2), were isolated from the acid hydrolysis product of a crude saponin fraction that was obtained from the fruits of Aesculus hippocastanum. The structures of 1 and 2 were determined from their chemical transformations and spectral data. Compound 1 is either 21-O-angeloyl, 22-O-tigloyl R1-barrigenol, or 21-O-tigloyl, 22-O-angeloyl R1-barrigenol.