The effect of quercetin on cell cycle progression and growth of human gastric cancer cells

作者：Mitsumori Yoshida, Toshiyuki Sakai, Nobuko Hosokawa, Nobuyuki Marui, Katsuhiko Matsumoto, Akihiro Fujioka, Hoyoku Nishino, Akira Aoike · 发表于：FEBS Letters · 年份：1990 · DOI：10.1016/0014-5793(90)80053-l · 被引用次数：321 · 研究领域：Genomics, phytochemicals, and oxidative stress、Phytochemicals and Antioxidant Activities、Cholesterol and Lipid Metabolism

Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and the IC50 value was 32-55 microM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 microM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G1 to the S phase.