Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine II. Mucous cells

作者：Hazel Cheng · 发表于：American Journal of Anatomy · 年份：1974 · DOI：10.1002/aja.1001410404 · 被引用次数：623 · 研究领域：Helicobacter pylori-related gastroenterology studies、Gastrointestinal disorders and treatments、Gastroesophageal reflux and treatments

Abstract The mucous cell population of duodenum, jejunum and ileum was investigated in the light and electron microscopes with the help of radioautography in mice sacrificed at various times after single injection or continuous infusion of 3 H‐thymidine. Mucous cells are characterized by globules of mucus and by dilated cisternae of rough endoplasmic reticulum. Two subgroups of mucous cells, one called common and the other granular , may be identified. The granular mucous cells differ from the common ones by the presence of small dense granules embedded within the mucous globules. Each subgroup is further divided into immature oligomucous cells containing few mucous globules, and mature goblet cells with a large accumulation of mucous globules. Common and granular oligomucous cells are found exclusively in the crypt, mainly within the lower mid‐crypt, whereas the corresponding two types of goblet cells are present in the upper part of the crypts and in the lower part of the villi. Only common mucous cells are observed in the upper part of the villi. The two types of oligomucous cells, but not goblet cells, have the ability to take up 3 H‐thymidine and divide. Electron microscopic radioautography demonstrates that, as oligomucous cells migrate upwards, they transform into goblet cells. The latter then migrate to the villus epithelium. In the case of granular mucous cells, this migration is associated with a gradual loss of the characteristic dense granules, so that the granula...