Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors

作者：Wendy L. Havran, Yueh-hsiu Chien, James Patrick Allison · 发表于：Science · 年份：1991 · DOI：10.1126/science.1828619 · 被引用次数：366 · 研究领域：T-cell and B-cell Immunology、Immunotherapy and Immune Responses、Toxin Mechanisms and Immunotoxins

Thy-1+ dendritic epidermal T cells (dECs) express invariant gamma delta antigen receptors and are found in intimate contact with keratinocytes in murine epidermis--thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells. Thy-1+ dECs were stimulated to produce lymphokines by interaction with keratinocytes in vitro. This stimulation was mediated through the dEC antigen receptor and did not appear to be restricted by the major histocompatibility complex. Thus, dECs can recognize self antigens and may participate in immune surveillance for cellular damage rather than for foreign antigens.