Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease

作者：Paul M. Ridker, Mary Cushman, Meir J. Stampfer, Russell P. Tracy, Charles H. Hennekens · 发表于：Circulation · 年份：1998 · DOI：10.1161/01.cir.97.5.425 · 被引用次数：983 · 研究领域：Peripheral Artery Disease Management、Adipokines, Inflammation, and Metabolic Diseases、Inflammatory Biomarkers in Disease Prognosis

BACKGROUND: Among apparently healthy men, elevated levels of C-reactive protein (CRP), a marker for systemic inflammation, predict risk of myocardial infarction and thromboembolic stroke. Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown. METHODS AND RESULTS: Using a prospective, nested, case-control design, we measured baseline levels of CRP in 144 apparently healthy men participating in the Physicians' Health Study who subsequently developed symptomatic PAD (intermittent claudication or need for revascularization) and in an equal number of control subjects matched on the basis of age and smoking habit who remained free of vascular disease during a follow-up period of 60 months. Median CRP levels at baseline were significantly higher among those who subsequently developed PAD (1.34 versus 0.99 mg/L; P=.04). Furthermore, the risks of developing PAD increased significantly with each increasing quartile of baseline CRP concentration such that relative risks of PAD from lowest (referent) to highest quartile of CRP were 1.0, 1.3, 2.0, and 2.1 (Ptrend=.02). Compared with those with no clinical evidence of disease, the subgroup of case patients who required revascularization had the highest baseline CRP levels (median= 1.75 mg/L; P= .04); relative risks from lowest to highest quartile of CRP for this end point were 1.0, 1.8, 3.8, and 4.1 (Ptrend=.02). Risk estimates were similar after additional cont...