Differentiation of porphyria cutanea tarda symptomatica from other types of porphyria by measurement of isocoproporphyrin in faeces.

作者：George H. Elder · 发表于：Journal of Clinical Pathology · 年份：1975 · DOI：10.1136/jcp.28.8.601 · 被引用次数：89 · 研究领域：Porphyrin Metabolism and Disorders、Heme Oxygenase-1 and Carbon Monoxide、Folate and B Vitamins Research

The faecal porphyrin patterns of 24 patients with porphyria cutanea tarda symptomatica (PCTS), eight patients with variegate porphyria, three patients with other types of porphyria, and 20 non-porphyrics subjects have been compared using a two-demensional thin layer chromatographic technique that separates porphyrins of the isocoproporphyrin series from other faecal porphyrins. The 'isocoproporphyrin': coproporphyrin ratio ranged from 0-1 to 5-6 for patients with PCTS, whereas in other types of porphyria and non-porphyric subjects it was 0-05 or less.