Human parvovirus B19 infection in hemophiliacs first infused with two high‐purity, virally attenuated factor Vlll concentrates

作者：Akel Azzi, S. Ciappi, K. Zakvrzewska, M. Morfini, Giuliano Mariani, Pier Mannuccio Mannucci · 发表于：American Journal of Hematology · 年份：1992 · DOI：10.1002/ajh.2830390315 · 被引用次数：168 · 研究领域：Parvovirus B19 Infection Studies、Dermatological and COVID-19 studies、Prenatal Screening and Diagnostics

Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high-purity concentrates reduces the risk of B19 transmission, we have prospectively evaluated the rate of anti-B19 seroconversion in two groups of susceptible (anti-B19 negative) hemophiliacs infused with high-purity, heated (pasteurized) or solvent-detergent-treated factor VIII concentrates. Both products infected a relatively high proportion of patients (nine of 20).